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• Methamphetamine blocks dopamine re-uptake, methamphetamine also increases the release of dopamine, leading to much higher concentrations in the synapse, which can be toxic to nerve terminals.
• In 1906, Coca Cola removed Cocaine from the Coca leaves used to make its product.
• One in ten high school seniors in the US admits to abusing prescription painkillers.
• 3.8% of twelfth graders reported having used Ritalin without a prescription at least once in the past year.
• In 2011, a Pennsylvania couple stabbed the walls in their apartment to attack the '90 people living in their walls.'
• 8.6% of 12th graders have used hallucinogens 4% report on using LSD specifically.
• The drug was first synthesized in the 1960's by Upjohn Pharmaceutical Company.
• Methamphetamine has also been used in the treatment of obesity.
• There were over 1.8 million Americans 12 or older who used a hallucinogen or inhalant for the first time. (1.1 million among hallucinogens)
• Pharmacological treatment for depression began with MAOIs and tricyclics dating back to the 1950's.
• Coca wine's (wine brewed with cocaine) most prominent brand, Vin Mariani, received endorsement for its beneficial effects from celebrities, scientists, physicians and even Pope Leo XIII.
• Krokodil is named for the crocodile-like appearance it creates on the skin. Over time, it damages blood vessels and causes the skin to become green and scaly. The tissue damage can lead to gangrene and result in amputation or death.
• Women born after World War 2 were more inclined to become alcoholics than those born before 1943.
• Gangs, whether street gangs, outlaw motorcycle gangs or even prison gangs, distribute more drugs on the streets of the U.S. than any other person or persons do.
• 60% of teens who have abused prescription painkillers did so before age 15.
• Decreased access to dopamine often results in symptoms similar to Parkinson's disease
• Women who had an alcoholic parent are more likely to become an alcoholic than men who have an alcoholic parent.
• 193,717 people were admitted to Drug rehabilitation or Alcohol rehabilitation programs in California in 2006.
• Out of all the benzodiazepine emergency room visits 78% of individuals are using other substances.
• 30% of emergency room admissions from prescription abuse involve opiate-based substances.